<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2026 Workiva-->
<!--r:019e2c46-815b-7ae6-aeca-5fd7464c69e6,g:0bc841a2-6e2e-4b50-98be-894460d35af8-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:arcroleRef arcroleURI="https://xbrl.org/2023/arcrole/summation-item" xlink:type="simple" xlink:href="https://www.xbrl.org/2023/calculation-1.1.xsd#summation-item"/>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/Condensedconsolidatedbalancesheets" xlink:type="simple" xlink:href="rmb-20260630.xsd#Condensedconsolidatedbalancesheets"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/Condensedconsolidatedbalancesheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e2c46-82b9-78de-8a32-a9a1b27ac8cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e2c46-82b9-72c3-a669-671453065a20" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e2c46-82b9-78de-8a32-a9a1b27ac8cd" xlink:to="loc_us-gaap_StockholdersEquity_019e2c46-82b9-72c3-a669-671453065a20" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_019e2c46-82b9-7f32-a83d-05531504fc36" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e2c46-82b9-78de-8a32-a9a1b27ac8cd" xlink:to="loc_us-gaap_CommitmentsAndContingencies_019e2c46-82b9-7f32-a83d-05531504fc36" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e2c46-82b9-7b57-ac30-1af204f7dde8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_019e2c46-82b9-78de-8a32-a9a1b27ac8cd" xlink:to="loc_us-gaap_Liabilities_019e2c46-82b9-7b57-ac30-1af204f7dde8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_019e2c46-82b9-7885-8e15-75fb4b92f3a0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_019e2c46-82b9-77fd-9a7b-dcac97f4e09c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e2c46-82b9-7885-8e15-75fb4b92f3a0" xlink:to="loc_us-gaap_CommonStockValue_019e2c46-82b9-77fd-9a7b-dcac97f4e09c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_019e2c46-82b9-7a61-bdba-0a56fd85360e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e2c46-82b9-7885-8e15-75fb4b92f3a0" xlink:to="loc_us-gaap_AdditionalPaidInCapital_019e2c46-82b9-7a61-bdba-0a56fd85360e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e2c46-82b9-762c-8be9-9e4675e8a048" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e2c46-82b9-7885-8e15-75fb4b92f3a0" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_019e2c46-82b9-762c-8be9-9e4675e8a048" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e2c46-82b9-7324-baf9-104684804131" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e2c46-82b9-7885-8e15-75fb4b92f3a0" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_019e2c46-82b9-7324-baf9-104684804131" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_019e2c46-82b9-7007-bcca-34c6119b0e8e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_019e2c46-82b9-7885-8e15-75fb4b92f3a0" xlink:to="loc_us-gaap_PreferredStockValue_019e2c46-82b9-7007-bcca-34c6119b0e8e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_019e2c46-82b9-71ef-adf2-f6a9d1f8eac0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_019e2c46-82b9-7cc9-ae0d-b4a7bb35cad6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e2c46-82b9-71ef-adf2-f6a9d1f8eac0" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_019e2c46-82b9-7cc9-ae0d-b4a7bb35cad6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rmb_LeaseLiabilityNoncurrent_019e2c46-82b9-7530-9c8c-18321fb2820c" xlink:href="rmb-20260630.xsd#rmb_LeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e2c46-82b9-71ef-adf2-f6a9d1f8eac0" xlink:to="loc_rmb_LeaseLiabilityNoncurrent_019e2c46-82b9-7530-9c8c-18321fb2820c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e2c46-82b9-766e-b422-70f01060c272" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e2c46-82b9-71ef-adf2-f6a9d1f8eac0" xlink:to="loc_us-gaap_LiabilitiesCurrent_019e2c46-82b9-766e-b422-70f01060c272" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019e2c46-82b9-7ff2-914a-df89653b341e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e2c46-82b9-71ef-adf2-f6a9d1f8eac0" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_019e2c46-82b9-7ff2-914a-df89653b341e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rmb_WarrantLiabilityNoncurrent_019e2c46-82b9-7b09-b2bf-9ed9cb6953c4" xlink:href="rmb-20260630.xsd#rmb_WarrantLiabilityNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_019e2c46-82b9-71ef-adf2-f6a9d1f8eac0" xlink:to="loc_rmb_WarrantLiabilityNoncurrent_019e2c46-82b9-7b09-b2bf-9ed9cb6953c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_019e2c46-82b9-7c10-b17b-6bb53a0463ab" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_rmb_LeaseRightOfUseAsset_019e2c46-82b9-7fd8-8946-af97000d4b5d" xlink:href="rmb-20260630.xsd#rmb_LeaseRightOfUseAsset"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e2c46-82b9-7c10-b17b-6bb53a0463ab" xlink:to="loc_rmb_LeaseRightOfUseAsset_019e2c46-82b9-7fd8-8946-af97000d4b5d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e2c46-82b9-7c42-b138-dc4937a23ef2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e2c46-82b9-7c10-b17b-6bb53a0463ab" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_019e2c46-82b9-7c42-b138-dc4937a23ef2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_019e2c46-82b9-7124-8e37-9b621cd59731" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e2c46-82b9-7c10-b17b-6bb53a0463ab" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_019e2c46-82b9-7124-8e37-9b621cd59731" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e2c46-82b9-7cbc-9464-c3d6906b3729" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e2c46-82b9-7c10-b17b-6bb53a0463ab" xlink:to="loc_us-gaap_AssetsCurrent_019e2c46-82b9-7cbc-9464-c3d6906b3729" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_019e2c46-82b9-745b-ba46-c8ec84ee0d8c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_019e2c46-82b9-7c10-b17b-6bb53a0463ab" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_019e2c46-82b9-745b-ba46-c8ec84ee0d8c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_019e2c46-82b9-749e-b9ad-822249434177" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019e2c46-82b9-7524-a598-35495cbe5d57" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e2c46-82b9-749e-b9ad-822249434177" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecuritiesCurrent_019e2c46-82b9-7524-a598-35495cbe5d57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e2c46-82b9-7788-8d5a-18613f78711f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e2c46-82b9-749e-b9ad-822249434177" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_019e2c46-82b9-7788-8d5a-18613f78711f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e2c46-82b9-7d17-9fa9-eb5a21cac4b3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e2c46-82b9-749e-b9ad-822249434177" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e2c46-82b9-7d17-9fa9-eb5a21cac4b3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019e2c46-82b9-7cd6-9b5a-faa9059201b5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e2c46-82b9-749e-b9ad-822249434177" xlink:to="loc_us-gaap_InventoryNet_019e2c46-82b9-7cd6-9b5a-faa9059201b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_019e2c46-82b9-7b7d-9175-ccaf0b60652e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_019e2c46-82b9-749e-b9ad-822249434177" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_019e2c46-82b9-7b7d-9175-ccaf0b60652e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_019e2c46-82b9-7c39-9e1a-0612238b0d66" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019e2c46-82b9-7445-a0bf-df0aabf0f673" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e2c46-82b9-7c39-9e1a-0612238b0d66" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_019e2c46-82b9-7445-a0bf-df0aabf0f673" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019e2c46-82b9-703c-9d58-f4d2d3df7d45" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e2c46-82b9-7c39-9e1a-0612238b0d66" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_019e2c46-82b9-703c-9d58-f4d2d3df7d45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_019e2c46-82b9-7412-aeea-9e2868e6de5b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e2c46-82b9-7c39-9e1a-0612238b0d66" xlink:to="loc_us-gaap_AccountsPayableCurrent_019e2c46-82b9-7412-aeea-9e2868e6de5b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rmb_LeaseLiabilityCurrent_019e2c46-82b9-7e90-901e-02fb9850fdb7" xlink:href="rmb-20260630.xsd#rmb_LeaseLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_019e2c46-82b9-7c39-9e1a-0612238b0d66" xlink:to="loc_rmb_LeaseLiabilityCurrent_019e2c46-82b9-7e90-901e-02fb9850fdb7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/Condensedconsolidatedstatementsofoperations" xlink:type="simple" xlink:href="rmb-20260630.xsd#Condensedconsolidatedstatementsofoperations"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/Condensedconsolidatedstatementsofoperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019e2c46-82b9-71a1-ab7f-e13642a70913" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_019e2c46-82b9-7a1b-be24-73bc6935f3b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e2c46-82b9-71a1-ab7f-e13642a70913" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_019e2c46-82b9-7a1b-be24-73bc6935f3b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseNonoperating_019e2c46-82b9-7518-ab05-4097cdbabb12" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InterestExpenseNonoperating"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e2c46-82b9-71a1-ab7f-e13642a70913" xlink:to="loc_us-gaap_InterestExpenseNonoperating_019e2c46-82b9-7518-ab05-4097cdbabb12" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_019e2c46-82b9-7f79-9f0d-854bd41970c0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_019e2c46-82b9-71a1-ab7f-e13642a70913" xlink:to="loc_us-gaap_InvestmentIncomeInterest_019e2c46-82b9-7f79-9f0d-854bd41970c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e2c46-82b9-774e-90b7-b4d90f36b948" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_019e2c46-82b9-7401-aee7-eb84764665cc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e2c46-82b9-774e-90b7-b4d90f36b948" xlink:to="loc_us-gaap_IncomeLossAttributableToParent_019e2c46-82b9-7401-aee7-eb84764665cc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_019e2c46-82b9-7cde-8ea9-458980359b21" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_019e2c46-82b9-774e-90b7-b4d90f36b948" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_019e2c46-82b9-7cde-8ea9-458980359b21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019e2c46-82b9-7f8e-8a7b-4902d2a353be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e2c46-82b9-7227-896e-798ce0eaa198" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019e2c46-82b9-7f8e-8a7b-4902d2a353be" xlink:to="loc_us-gaap_RevenueFromContractWithCustomerExcludingAssessedTax_019e2c46-82b9-7227-896e-798ce0eaa198" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_019e2c46-82b9-77a3-89d0-ca60b6ef9be0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_019e2c46-82b9-7f8e-8a7b-4902d2a353be" xlink:to="loc_us-gaap_CostOfRevenue_019e2c46-82b9-77a3-89d0-ca60b6ef9be0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e2c46-82b9-75dc-aafd-b8a444e98ce3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_019e2c46-82b9-7981-8074-bc0c2635bec9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e2c46-82b9-75dc-aafd-b8a444e98ce3" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_019e2c46-82b9-7981-8074-bc0c2635bec9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingAndMarketingExpense_019e2c46-82b9-7667-a997-ada1ff1ce2b8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_SellingAndMarketingExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e2c46-82b9-75dc-aafd-b8a444e98ce3" xlink:to="loc_us-gaap_SellingAndMarketingExpense_019e2c46-82b9-7667-a997-ada1ff1ce2b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_019e2c46-82b9-7a0e-9946-13e577a733de" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_019e2c46-82b9-75dc-aafd-b8a444e98ce3" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_019e2c46-82b9-7a0e-9946-13e577a733de" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossAttributableToParent_019e2c46-82b9-7532-a437-ab0cf96b2abf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncomeLossAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_019e2c46-82b9-7917-9dd9-65028db4f4a8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_019e2c46-82b9-7532-a437-ab0cf96b2abf" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_019e2c46-82b9-7917-9dd9-65028db4f4a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e2c46-82b9-7692-9888-e3e23c6a94e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_IncomeLossAttributableToParent_019e2c46-82b9-7532-a437-ab0cf96b2abf" xlink:to="loc_us-gaap_OperatingIncomeLoss_019e2c46-82b9-7692-9888-e3e23c6a94e0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_019e2c46-82b9-7818-9ee2-0693a331b934" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_019e2c46-82b9-7a28-a062-fb5f06b5adf3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e2c46-82b9-7818-9ee2-0693a331b934" xlink:to="loc_us-gaap_OperatingExpenses_019e2c46-82b9-7a28-a062-fb5f06b5adf3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_019e2c46-82b9-77c7-a79e-3e94112c6643" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_019e2c46-82b9-7818-9ee2-0693a331b934" xlink:to="loc_us-gaap_GrossProfit_019e2c46-82b9-77c7-a79e-3e94112c6643" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/Condensedconsolidatedstatementsofcomprehensiveloss" xlink:type="simple" xlink:href="rmb-20260630.xsd#Condensedconsolidatedstatementsofcomprehensiveloss"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/Condensedconsolidatedstatementsofcomprehensiveloss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e2c46-82b9-79ca-92be-99e276f0eed4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e2c46-82b9-7ccd-ba3a-2e79e873a921" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e2c46-82b9-79ca-92be-99e276f0eed4" xlink:to="loc_us-gaap_NetIncomeLoss_019e2c46-82b9-7ccd-ba3a-2e79e873a921" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019e2c46-82b9-743f-b23e-de708f10914f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_019e2c46-82b9-79ca-92be-99e276f0eed4" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossAvailableForSaleSecuritiesAdjustmentNetOfTax_019e2c46-82b9-743f-b23e-de708f10914f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/Condensedconsolidatedstatementsofcashflows" xlink:type="simple" xlink:href="rmb-20260630.xsd#Condensedconsolidatedstatementsofcashflows"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/Condensedconsolidatedstatementsofcashflows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_019e2c46-82b9-7e9e-a2df-f2c3aa1a11c8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_NetIncomeLoss_019e2c46-82b9-7e9e-a2df-f2c3aa1a11c8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_019e2c46-82b9-74ab-9608-8fe5b747848c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_019e2c46-82b9-74ab-9608-8fe5b747848c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_019e2c46-82b9-74ed-aa4a-1d0484bc49c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_ShareBasedCompensation_019e2c46-82b9-74ed-aa4a-1d0484bc49c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWriteDown_019e2c46-82b9-7c35-aff6-9073cc0ecb0e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWriteDown"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_InventoryWriteDown_019e2c46-82b9-7c35-aff6-9073cc0ecb0e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rmb_LeasesNoncashExpense_019e2c46-82b9-74dc-837b-a0935193c3a5" xlink:href="rmb-20260630.xsd#rmb_LeasesNoncashExpense"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_rmb_LeasesNoncashExpense_019e2c46-82b9-74dc-837b-a0935193c3a5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rmb_AccretionOfDebtSecuritiesAvailableForSale_019e2c46-82b9-7f6f-90de-5d0e797518b8" xlink:href="rmb-20260630.xsd#rmb_AccretionOfDebtSecuritiesAvailableForSale"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_rmb_AccretionOfDebtSecuritiesAvailableForSale_019e2c46-82b9-7f6f-90de-5d0e797518b8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e2c46-82b9-7885-bb20-e7484303b894" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_019e2c46-82b9-7885-bb20-e7484303b894" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_019e2c46-82b9-7193-93f2-1870a0037cc1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_019e2c46-82b9-7193-93f2-1870a0037cc1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019e2c46-82b9-7952-9529-c5a074f7dd15" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_019e2c46-82b9-7952-9529-c5a074f7dd15" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019e2c46-82b9-74e2-a282-fe65b2c606a1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInOtherNoncurrentAssets"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherNoncurrentAssets_019e2c46-82b9-74e2-a282-fe65b2c606a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019e2c46-82b9-7c4e-8e1a-ef5c1590633c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_019e2c46-82b9-7c4e-8e1a-ef5c1590633c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_019e2c46-82b9-7f16-b1b8-b47f6b9fd63e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilitiesAndOtherOperatingLiabilities_019e2c46-82b9-7f16-b1b8-b47f6b9fd63e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019e2c46-82b9-7925-bf57-24c47d0e82be" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_019e2c46-82b9-7925-bf57-24c47d0e82be" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_019e2c46-82b9-73ba-8671-0e418c42febb" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_019e2c46-82b9-73ba-8671-0e418c42febb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_019e2c46-82b9-7221-b093-e1061be90615" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AmortizationOfFinancingCostsAndDiscounts"/>
    <link:calculationArc order="15" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_AmortizationOfFinancingCostsAndDiscounts_019e2c46-82b9-7221-b093-e1061be90615" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_019e2c46-82b9-74fd-8a2d-fdbde7afaada" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="16" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7bf0-863a-cbccec874ea8" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_019e2c46-82b9-74fd-8a2d-fdbde7afaada" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_019e2c46-82b9-7f4b-b6cf-8e304a815756" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7e6f-af00-53f8f01bed12" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_019e2c46-82b9-7f4b-b6cf-8e304a815756" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_019e2c46-82b9-7e6f-af00-53f8f01bed12" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e2c46-82b9-7e0b-8033-0091e0546569" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_019e2c46-82b9-7f4b-b6cf-8e304a815756" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e2c46-82b9-7e0b-8033-0091e0546569" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e2c46-82b9-73c6-a488-f232b76e4576" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseExcludingExchangeRateEffect_019e2c46-82b9-7f4b-b6cf-8e304a815756" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e2c46-82b9-73c6-a488-f232b76e4576" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e2c46-82b9-7c0c-9cbb-595f15de7b94" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_019e2c46-82b9-76bf-8249-360a269e6f13" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e2c46-82b9-7c0c-9cbb-595f15de7b94" xlink:to="loc_us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt_019e2c46-82b9-76bf-8249-360a269e6f13" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e2c46-82b9-7522-823f-2141dd3e225f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e2c46-82b9-7c0c-9cbb-595f15de7b94" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_019e2c46-82b9-7522-823f-2141dd3e225f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019e2c46-82b9-7493-9bc9-78035fac2b6d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e2c46-82b9-7c0c-9cbb-595f15de7b94" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfAvailableForSaleSecurities_019e2c46-82b9-7493-9bc9-78035fac2b6d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_019e2c46-82b9-767e-ba66-65cd64382106" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_019e2c46-82b9-7c0c-9cbb-595f15de7b94" xlink:to="loc_us-gaap_ProceedsFromSaleOfAvailableForSaleSecuritiesDebt_019e2c46-82b9-767e-ba66-65cd64382106" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e2c46-82b9-7520-8774-8239f3eb0ee3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019e2c46-82b9-738e-9e9c-15e4b7a1e23f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e2c46-82b9-7520-8774-8239f3eb0ee3" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlansIncludingStockOptions_019e2c46-82b9-738e-9e9c-15e4b7a1e23f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockPlans_019e2c46-82b9-7950-9e96-2ef40c22c879" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromStockPlans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e2c46-82b9-7520-8774-8239f3eb0ee3" xlink:to="loc_us-gaap_ProceedsFromStockPlans_019e2c46-82b9-7950-9e96-2ef40c22c879" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019e2c46-82b9-70e1-b58f-01028be6c6d4" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e2c46-82b9-7520-8774-8239f3eb0ee3" xlink:to="loc_us-gaap_PaymentsRelatedToTaxWithholdingForShareBasedCompensation_019e2c46-82b9-70e1-b58f-01028be6c6d4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPrivatePlacement_019f8867-8a3d-7748-85ec-0b8cd58f1c3a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ProceedsFromIssuanceOfPrivatePlacement"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e2c46-82b9-7520-8774-8239f3eb0ee3" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPrivatePlacement_019f8867-8a3d-7748-85ec-0b8cd58f1c3a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_019f8867-8a3d-7cdb-a6d8-39b0cb88a041" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e2c46-82b9-7520-8774-8239f3eb0ee3" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_019f8867-8a3d-7cdb-a6d8-39b0cb88a041" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeasePrincipalPayments_019fb322-fb2a-7e9d-b64c-db8bb627b42f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeasePrincipalPayments"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_019e2c46-82b9-7520-8774-8239f3eb0ee3" xlink:to="loc_us-gaap_FinanceLeasePrincipalPayments_019fb322-fb2a-7e9d-b64c-db8bb627b42f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/FairvalueoffinancialassetsandliabilitiesScheduleofAssetsandLiabilitiesMeasuredonaRecurringBasisDetails" xlink:type="simple" xlink:href="rmb-20260630.xsd#FairvalueoffinancialassetsandliabilitiesScheduleofAssetsandLiabilitiesMeasuredonaRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/FairvalueoffinancialassetsandliabilitiesScheduleofAssetsandLiabilitiesMeasuredonaRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_019e2c46-82b9-7072-bd26-a624bee30fb0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019e2c46-82b9-74da-a2d7-01c9ac45cb52" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_019e2c46-82b9-7072-bd26-a624bee30fb0" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_019e2c46-82b9-74da-a2d7-01c9ac45cb52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019e2c46-82b9-72f0-b4b0-fe5f3f5a8bf7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsFairValueDisclosure_019e2c46-82b9-7072-bd26-a624bee30fb0" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019e2c46-82b9-72f0-b4b0-fe5f3f5a8bf7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesFairValueDisclosure_019e2c46-82b9-796d-98fc-b5e964b6ac0c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LiabilitiesFairValueDisclosure"/>
    <link:loc xlink:type="locator" xlink:label="loc_rmb_WarrantLiabilityFairValueDisclosure_019e2c46-82b9-75db-a5e8-bde4077a92d7" xlink:href="rmb-20260630.xsd#rmb_WarrantLiabilityFairValueDisclosure"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesFairValueDisclosure_019e2c46-82b9-796d-98fc-b5e964b6ac0c" xlink:to="loc_rmb_WarrantLiabilityFairValueDisclosure_019e2c46-82b9-75db-a5e8-bde4077a92d7" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/InvestmentsDetails" xlink:type="simple" xlink:href="rmb-20260630.xsd#InvestmentsDetails"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/InvestmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAfterAllowanceForCreditLoss_019e2c46-82b9-7fa3-a951-bc2edf4dddf9" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAfterAllowanceForCreditLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019e2c46-82b9-72f7-b36e-8895052cdc69" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAfterAllowanceForCreditLoss_019e2c46-82b9-7fa3-a951-bc2edf4dddf9" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_019e2c46-82b9-72f7-b36e-8895052cdc69" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019e2c46-82b9-7160-9d87-737862e9c86c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAfterAllowanceForCreditLoss_019e2c46-82b9-7fa3-a951-bc2edf4dddf9" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_019e2c46-82b9-7160-9d87-737862e9c86c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019e2c46-82b9-79b0-8c02-3e807c9b4a70" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_DebtSecuritiesAvailableForSaleAmortizedCostAfterAllowanceForCreditLoss_019e2c46-82b9-7fa3-a951-bc2edf4dddf9" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_019e2c46-82b9-79b0-8c02-3e807c9b4a70" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/InventorynetScheduleofInventoryDetails" xlink:type="simple" xlink:href="rmb-20260630.xsd#InventorynetScheduleofInventoryDetails"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/InventorynetScheduleofInventoryDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_019e2c46-82b9-77e3-93ed-9894215b9a8f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019e2c46-82b9-7ebd-91f4-614bd3bcf5c1" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryRawMaterialsNetOfReserves"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019e2c46-82b9-77e3-93ed-9894215b9a8f" xlink:to="loc_us-gaap_InventoryRawMaterialsNetOfReserves_019e2c46-82b9-7ebd-91f4-614bd3bcf5c1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019e2c46-82b9-7ab5-a3f8-89c959517c3f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryWorkInProcessNetOfReserves"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019e2c46-82b9-77e3-93ed-9894215b9a8f" xlink:to="loc_us-gaap_InventoryWorkInProcessNetOfReserves_019e2c46-82b9-7ab5-a3f8-89c959517c3f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019e2c46-82b9-775a-bf48-33333aa3686d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_InventoryFinishedGoodsNetOfReserves"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_019e2c46-82b9-77e3-93ed-9894215b9a8f" xlink:to="loc_us-gaap_InventoryFinishedGoodsNetOfReserves_019e2c46-82b9-775a-bf48-33333aa3686d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/PrepaidexpensesandothercurrentassetsDetails" xlink:type="simple" xlink:href="rmb-20260630.xsd#PrepaidexpensesandothercurrentassetsDetails"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/PrepaidexpensesandothercurrentassetsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e2c46-82b9-766a-b9f0-9ac3cc524d0b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerAssetNetCurrent_019e2c46-82b9-7927-9c5f-848630701f6e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_ContractWithCustomerAssetNetCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e2c46-82b9-766a-b9f0-9ac3cc524d0b" xlink:to="loc_us-gaap_ContractWithCustomerAssetNetCurrent_019e2c46-82b9-7927-9c5f-848630701f6e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsCurrent_019e2c46-82b9-7718-b647-eddf65147b90" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAssetsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e2c46-82b9-766a-b9f0-9ac3cc524d0b" xlink:to="loc_us-gaap_OtherAssetsCurrent_019e2c46-82b9-7718-b647-eddf65147b90" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidInsurance_019e2c46-82b9-7db4-b6ff-a6914b02e79a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PrepaidInsurance"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e2c46-82b9-766a-b9f0-9ac3cc524d0b" xlink:to="loc_us-gaap_PrepaidInsurance_019e2c46-82b9-7db4-b6ff-a6914b02e79a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepositsAssetsCurrent_019e2c46-82b9-76c6-8700-a2de007fe7f6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DepositsAssetsCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e2c46-82b9-766a-b9f0-9ac3cc524d0b" xlink:to="loc_us-gaap_DepositsAssetsCurrent_019e2c46-82b9-76c6-8700-a2de007fe7f6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredOfferingCosts_019e2c46-82b9-72b9-8a8d-2a980475c80f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredOfferingCosts"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_019e2c46-82b9-766a-b9f0-9ac3cc524d0b" xlink:to="loc_us-gaap_DeferredOfferingCosts_019e2c46-82b9-72b9-8a8d-2a980475c80f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/PropertyandequipmentnetScheduleofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="rmb-20260630.xsd#PropertyandequipmentnetScheduleofPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/PropertyandequipmentnetScheduleofPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_019e2c46-82b9-7ffa-8f61-1d62ec000f20" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_019e2c46-82b9-7680-925b-edd7b71a7ae8" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019e2c46-82b9-7ffa-8f61-1d62ec000f20" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_019e2c46-82b9-7680-925b-edd7b71a7ae8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019e2c46-82b9-7c6d-b6ce-15e9622c6a1c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_019e2c46-82b9-7ffa-8f61-1d62ec000f20" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_019e2c46-82b9-7c6d-b6ce-15e9622c6a1c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/AccruedexpenseandothercurrentliabilitiesDetails" xlink:type="simple" xlink:href="rmb-20260630.xsd#AccruedexpenseandothercurrentliabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/AccruedexpenseandothercurrentliabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_019e2c46-82b9-768f-9968-de65224cd9cf" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StandardProductWarrantyAccrualCurrent_019e2c46-82b9-75e9-b0e7-ec8bc6a7aeaa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_StandardProductWarrantyAccrualCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e2c46-82b9-768f-9968-de65224cd9cf" xlink:to="loc_us-gaap_StandardProductWarrantyAccrualCurrent_019e2c46-82b9-75e9-b0e7-ec8bc6a7aeaa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rmb_VendorAccrualsCurrent_019e2c46-82b9-7dfa-bc72-43ee5bfb3768" xlink:href="rmb-20260630.xsd#rmb_VendorAccrualsCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e2c46-82b9-768f-9968-de65224cd9cf" xlink:to="loc_rmb_VendorAccrualsCurrent_019e2c46-82b9-7dfa-bc72-43ee5bfb3768" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e2c46-82b9-7c70-8106-5bb97627d328" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e2c46-82b9-768f-9968-de65224cd9cf" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_019e2c46-82b9-7c70-8106-5bb97627d328" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_019e2c46-82b9-74a3-b692-cffaae7509c5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e2c46-82b9-768f-9968-de65224cd9cf" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_019e2c46-82b9-74a3-b692-cffaae7509c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019e2c46-82b9-7957-8dec-e42ec6060caa" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OtherAccruedLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrent_019e2c46-82b9-768f-9968-de65224cd9cf" xlink:to="loc_us-gaap_OtherAccruedLiabilitiesCurrent_019e2c46-82b9-7957-8dec-e42ec6060caa" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/NotespayablenetScheduleofNotesPayableNetDetails" xlink:type="simple" xlink:href="rmb-20260630.xsd#NotespayablenetScheduleofNotesPayableNetDetails"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/NotespayablenetScheduleofNotesPayableNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_019e2c46-82b9-7eb2-bce9-155143efc7e0" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_019e2c46-82b9-7e35-929d-5eca3698f273" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019e2c46-82b9-7eb2-bce9-155143efc7e0" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_019e2c46-82b9-7e35-929d-5eca3698f273" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rmb_UnamortizedDebtOnWarrantLiability_019e2c46-82b9-7a34-995a-802017030c35" xlink:href="rmb-20260630.xsd#rmb_UnamortizedDebtOnWarrantLiability"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019e2c46-82b9-7eb2-bce9-155143efc7e0" xlink:to="loc_rmb_UnamortizedDebtOnWarrantLiability_019e2c46-82b9-7a34-995a-802017030c35" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_019e2c46-82b9-7e22-9821-4076f86320a7" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019e2c46-82b9-7eb2-bce9-155143efc7e0" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_019e2c46-82b9-7e22-9821-4076f86320a7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rmb_LongTermDebtAccretion_019e2c46-82b9-7edf-8595-671d41ed7130" xlink:href="rmb-20260630.xsd#rmb_LongTermDebtAccretion"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebtNoncurrent_019e2c46-82b9-7eb2-bce9-155143efc7e0" xlink:to="loc_rmb_LongTermDebtAccretion_019e2c46-82b9-7edf-8595-671d41ed7130" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/NotespayablenetScheduleofDebtPrincipalPaymentsDetails" xlink:type="simple" xlink:href="rmb-20260630.xsd#NotespayablenetScheduleofDebtPrincipalPaymentsDetails"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/NotespayablenetScheduleofDebtPrincipalPaymentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_019e2c46-82b9-7b56-a098-3785034682e6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019e2c46-82b9-7c3f-927a-21830190d50f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e2c46-82b9-7b56-a098-3785034682e6" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_019e2c46-82b9-7c3f-927a-21830190d50f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019e2c46-82b9-7cff-ad9e-df2d5b4f3959" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e2c46-82b9-7b56-a098-3785034682e6" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_019e2c46-82b9-7cff-ad9e-df2d5b4f3959" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_019e2c46-82b9-7505-9ab9-6b78743735bc" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e2c46-82b9-7b56-a098-3785034682e6" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_019e2c46-82b9-7505-9ab9-6b78743735bc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_019e2c46-82b9-7ea9-8e30-93c62a5666cd" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e2c46-82b9-7b56-a098-3785034682e6" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_019e2c46-82b9-7ea9-8e30-93c62a5666cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_019e2c46-82b9-7671-9dd2-2e19a3b99897" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_019e2c46-82b9-7b56-a098-3785034682e6" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_019e2c46-82b9-7671-9dd2-2e19a3b99897" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/LeasesScheduleofSupplementalBalanceSheetInformationDetails" xlink:type="simple" xlink:href="rmb-20260630.xsd#LeasesScheduleofSupplementalBalanceSheetInformationDetails"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/LeasesScheduleofSupplementalBalanceSheetInformationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_019e2c46-8384-7fae-8d41-910facc061df" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_019e2c46-8384-7205-bb66-2ea9fa677ce5" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiability_019e2c46-8384-7fae-8d41-910facc061df" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_019e2c46-8384-7205-bb66-2ea9fa677ce5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_019e2c46-8384-73ea-b62e-56f4bfebcf06" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiability_019e2c46-8384-7fae-8d41-910facc061df" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_019e2c46-8384-73ea-b62e-56f4bfebcf06" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019e2c46-8384-7d82-a971-0a1f6fa30d49" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e2c46-8384-709a-9b12-c0b69580b331" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019e2c46-8384-7d82-a971-0a1f6fa30d49" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_019e2c46-8384-709a-9b12-c0b69580b331" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e2c46-8384-7742-b5f7-494d8bbc21a6" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingLeaseLiability_019e2c46-8384-7d82-a971-0a1f6fa30d49" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_019e2c46-8384-7742-b5f7-494d8bbc21a6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_019e2c46-8384-7386-8413-eb6ed6512ae3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetAccumulatedAmortization_019e2c46-8384-7dd3-b7e2-8cbabe993998" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseRightOfUseAssetAccumulatedAmortization"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseRightOfUseAsset_019e2c46-8384-7386-8413-eb6ed6512ae3" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetAccumulatedAmortization_019e2c46-8384-7dd3-b7e2-8cbabe993998" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetBeforeAccumulatedAmortization_019e2c46-8384-78e5-9882-c387a831b03d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseRightOfUseAssetBeforeAccumulatedAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseRightOfUseAsset_019e2c46-8384-7386-8413-eb6ed6512ae3" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetBeforeAccumulatedAmortization_019e2c46-8384-78e5-9882-c387a831b03d" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/LeasesScheduleofLeaseExpenseDetails" xlink:type="simple" xlink:href="rmb-20260630.xsd#LeasesScheduleofLeaseExpenseDetails"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/LeasesScheduleofLeaseExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseCost_019e2c46-8384-7088-850f-9a2b182c97d2" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LeaseCost"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseCost_019e2c46-8384-7c6e-9811-b5c4f7a04eba" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseCost"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019e2c46-8384-7088-850f-9a2b182c97d2" xlink:to="loc_us-gaap_OperatingLeaseCost_019e2c46-8384-7c6e-9811-b5c4f7a04eba" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_019e2c46-8384-7ab3-95dd-946810a5fc34" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseRightOfUseAssetAmortization"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019e2c46-8384-7088-850f-9a2b182c97d2" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_019e2c46-8384-7ab3-95dd-946810a5fc34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_rmb_FinanceLeaseInterestExpenseIncludingAdjustments_019e2c46-8384-722d-b332-167ae5d77313" xlink:href="rmb-20260630.xsd#rmb_FinanceLeaseInterestExpenseIncludingAdjustments"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019e2c46-8384-7088-850f-9a2b182c97d2" xlink:to="loc_rmb_FinanceLeaseInterestExpenseIncludingAdjustments_019e2c46-8384-722d-b332-167ae5d77313" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableLeaseCost_019e2c46-8384-79bf-b427-9c3417f1798f" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_VariableLeaseCost"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LeaseCost_019e2c46-8384-7088-850f-9a2b182c97d2" xlink:to="loc_us-gaap_VariableLeaseCost_019e2c46-8384-79bf-b427-9c3417f1798f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/LeasesScheduleofOperatingLeaseLiabilityMaturitiesDetails" xlink:type="simple" xlink:href="rmb-20260630.xsd#LeasesScheduleofOperatingLeaseLiabilityMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/LeasesScheduleofOperatingLeaseLiabilityMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e2c46-8384-717b-be6f-654ab2794666" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019e2c46-8384-7c37-bad6-53438395181b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e2c46-8384-717b-be6f-654ab2794666" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree_019e2c46-8384-7c37-bad6-53438395181b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019e2c46-8384-720e-b47d-6aa4a921f6af" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e2c46-8384-717b-be6f-654ab2794666" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo_019e2c46-8384-720e-b47d-6aa4a921f6af" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019e2c46-8384-75ec-9d71-893c0264c767" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e2c46-8384-717b-be6f-654ab2794666" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths_019e2c46-8384-75ec-9d71-893c0264c767" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019e2c46-8384-7439-b883-17984536c46e" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e2c46-8384-717b-be6f-654ab2794666" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear_019e2c46-8384-7439-b883-17984536c46e" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/LeasesScheduleofOperatingLeaseLiabilityMaturitiesDetails_1" xlink:type="simple" xlink:href="rmb-20260630.xsd#LeasesScheduleofOperatingLeaseLiabilityMaturitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/LeasesScheduleofOperatingLeaseLiabilityMaturitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e2c46-8384-7867-bb44-a57ad9e8fa2c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019e2c46-8384-7856-ad5d-8e50d275f209" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e2c46-8384-7867-bb44-a57ad9e8fa2c" xlink:to="loc_us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount_019e2c46-8384-7856-ad5d-8e50d275f209" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiability_019e2c46-8384-7669-b9ae-76b1339abb21" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_OperatingLeaseLiability"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue_019e2c46-8384-7867-bb44-a57ad9e8fa2c" xlink:to="loc_us-gaap_OperatingLeaseLiability_019e2c46-8384-7669-b9ae-76b1339abb21" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/LeasesScheduleofFinanceLeaseLiabilityMaturitiesDetails" xlink:type="simple" xlink:href="rmb-20260630.xsd#LeasesScheduleofFinanceLeaseLiabilityMaturitiesDetails"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/LeasesScheduleofFinanceLeaseLiabilityMaturitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019e2c46-8384-7b1b-a78d-126674a4c70a" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_019e2c46-8384-7148-b445-ecb50fc98a4c" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019e2c46-8384-7b1b-a78d-126674a4c70a" xlink:to="loc_us-gaap_FinanceLeaseLiability_019e2c46-8384-7148-b445-ecb50fc98a4c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_019e2c46-8384-708f-ae6e-35f61a2c9308" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019e2c46-8384-7b1b-a78d-126674a4c70a" xlink:to="loc_us-gaap_FinanceLeaseLiabilityUndiscountedExcessAmount_019e2c46-8384-708f-ae6e-35f61a2c9308" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.rapidmicrobio.com/role/LeasesScheduleofFinanceLeaseLiabilityMaturitiesDetails_1" xlink:type="simple" xlink:href="rmb-20260630.xsd#LeasesScheduleofFinanceLeaseLiabilityMaturitiesDetails_1"/>
  <link:calculationLink xlink:role="http://www.rapidmicrobio.com/role/LeasesScheduleofFinanceLeaseLiabilityMaturitiesDetails_1" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019e2c46-8384-772c-862c-024f50bb317d" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_019e2c46-8384-76cd-b87e-834a54dcfa2b" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019e2c46-8384-772c-862c-024f50bb317d" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearThree_019e2c46-8384-76cd-b87e-834a54dcfa2b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_019e2c46-8384-7b48-a1bd-22ab808b2355" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019e2c46-8384-772c-862c-024f50bb317d" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueYearTwo_019e2c46-8384-7b48-a1bd-22ab808b2355" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_019e2c46-8384-7a01-8361-ba7da9683b79" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019e2c46-8384-772c-862c-024f50bb317d" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsDueNextTwelveMonths_019e2c46-8384-7a01-8361-ba7da9683b79" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear_019e2c46-8384-7f27-afcd-632532a67ba3" xlink:href="https://xbrl.fasb.org/us-gaap/2026/elts/us-gaap-2026.xsd#us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="https://xbrl.org/2023/arcrole/summation-item" xlink:from="loc_us-gaap_FinanceLeaseLiabilityPaymentsDue_019e2c46-8384-772c-862c-024f50bb317d" xlink:to="loc_us-gaap_FinanceLeaseLiabilityPaymentsRemainderOfFiscalYear_019e2c46-8384-7f27-afcd-632532a67ba3" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
